https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42661 Wed 31 Aug 2022 13:44:21 AEST ]]> Towards a framework for better understanding of quiescent cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45157 Wed 26 Oct 2022 13:54:59 AEDT ]]> GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47696 Wed 25 Jan 2023 08:57:08 AEDT ]]> LncRNA IDH1-AS1 links the functions of c-Myc and HIF1a via IDH1 to regulate the Warburg effect https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47540 Wed 24 Jan 2024 15:22:27 AEDT ]]> ACTN4 regulates the stability of RIPK1 in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37515 Wed 23 Aug 2023 09:36:21 AEST ]]> BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30575 Wed 20 Mar 2019 12:05:15 AEDT ]]> c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37757 ARF in human and p19ARF in mouse) that binds to and inhibits mouse double minute 2 homolog (MDM2) leading to p53 activation, whereas p53 suppresses c-Myc through a combination of mechanisms involving transcriptional inactivation and microRNA-mediated repression. Nonetheless, the regulatory interactions between c-Myc and p53 are not retained by cancer cells as is evident from the often-imbalanced expression of c-Myc over wildtype p53. Although p53 repression in cancer cells is frequently associated with the loss of ARF, we disclose here an alternate mechanism whereby c-Myc inactivates p53 through the actions of the c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP). MILIP functions to promote p53 polyubiquitination and turnover by reducing p53 SUMOylation through suppressing tripartite-motif family-like 2 (TRIML2). MILIP upregulation is observed amongst diverse cancer types and is shown to support cell survival, division and tumourigenicity. Thus our results uncover an inhibitory axis targeting p53 through a pan-cancer expressed RNA accomplice that links c-Myc to suppression of p53.]]> Wed 17 Nov 2021 16:28:34 AEDT ]]> Cooperativity of HOXA5 and STAT3 is critical for HDAC8 inhibition-mediated transcriptional Activation of PD-L1 in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32982 Wed 17 Nov 2021 16:28:27 AEDT ]]> Histone deacetylases (HDACs) as mediators of resistance to apoptosis in melanoma and as targets for combination therapy with selective BRAF inhibitors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27649 Wed 17 May 2017 11:47:32 AEST ]]> LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53-Defective Cancer Cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50273 Wed 12 Jul 2023 14:18:12 AEST ]]> Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19023 V600E or MEK downregulated Noxa, whereas activation of MEK/ERK caused its upregulation. In addition, introduction of BRAFV600E increased Noxa expression in melanocytes. Upregulation of Noxa was due to a transcriptional increase mediated by cAMP responsive element binding protein, activation of which was also increased by MEK/ERK signaling in melanoma cells. Significantly, Noxa appeared necessary for constitutive activation of autophagy, albeit at low levels, by MEK/ERK in melanoma cells. Furthermore, it was required for autophagy activation that delayed apoptosis in melanoma cells undergoing nutrient deprivation. These results reveal that oncogenic activation of MEK/ERK drives Noxa expression to promote autophagy, and suggest that Noxa has an indirect anti-apoptosis role in melanoma cells under nutrient starvation conditions.]]> Wed 11 Apr 2018 16:41:25 AEST ]]> Oncogenic activation of MEK/ERK primes melanoma cells for adaptation to endoplasmic reticulum stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14866 Wed 11 Apr 2018 16:08:27 AEST ]]> MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13811 Wed 11 Apr 2018 15:41:21 AEST ]]> Loss of PI(4,5)P₂ 5-phosphatase A contributes to resistance of human melanoma cells to RAF/MEK inhibitors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14384 V600E and by the MEK inhibitor U0126 in both BRAFV600E and wild-type BRAF melanoma cells. This was due to inhibition of PI3K/Akt, as co-introduction of an active form of Akt (myr-Akt) abolished the effect of overexpression of PIB5PA on apoptosis induced by PLX4720 or U0126. While overexpression of PIB5PA triggered activation of Bad and down-regulation of Mcl-1, knockdown of Bad or overexpression of Mcl-1 recapitulated, at least in part, the effect of myr-Akt, suggesting that regulation of Bad and Mcl-1 is involved in PIB5PA-mediated sensitization of melanoma cells to the inhibitors. The role of PIB5PA deficiency in BRAF inhibitor resistance was confirmed by knockdown of PIB5PA, which led to increased growth of BRAFV600E melanoma cells selected for resistance to PLX4720. Consistent with its role in vitro, overexpression of PIB5PA and the MEK inhibitor selumetinib cooperatively inhibited melanoma tumor growth in a xenograft model. Taken together, these results identify loss of PIB5PA as a novel resistance mechanism of melanoma to RAF/MEK inhibitors and suggest that restoration of PIB5PA may be a useful strategy to improve the therapeutic efficacy of the inhibitors in the treatment of melanoma.]]> Wed 11 Apr 2018 14:44:27 AEST ]]> RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28314 Wed 11 Apr 2018 12:40:55 AEST ]]> PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14353 Wed 11 Apr 2018 11:50:58 AEST ]]> Reactive oxygen species dictate the apoptotic response of melanoma cells to TH588 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28216 Wed 11 Apr 2018 09:38:40 AEST ]]> INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22865 Wed 11 Apr 2018 09:31:09 AEST ]]> BAG3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32985 Wed 10 Nov 2021 15:04:52 AEDT ]]> Skp2-mediated stabilization of MTH1 promotes survival of melanoma cells upon oxidative stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32181 Wed 09 Mar 2022 15:58:36 AEDT ]]> Cylindromatosis is required for survival of a subset of melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39074 Wed 04 May 2022 15:24:42 AEST ]]> Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28215 Wed 02 Mar 2022 14:25:48 AEDT ]]> PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54544 Tue 27 Feb 2024 20:39:49 AEDT ]]> The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51136 Tue 22 Aug 2023 15:58:29 AEST ]]> Development of in silico methodology for siRNA lipid nanoparticle formulations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46983 Tue 13 Dec 2022 09:07:30 AEDT ]]> A p53-responsive miRNA network promotes cancer cell quiescence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35745 chromosome 9 open reading frame 3 gene that was transcriptionally activated by p53. Similarly, the host gene of miRNA-455-3p, collagen alpha-1 (XXVII) chain, was also a p53 transcriptional target. Collectively, our results identify miRNA-27b-3p and miRNA-455-3p as important regulators of cancer cell quiescence in response to p53 and suggest that manipulating miRNA-27b-3p and miRNA-455-3p may constitute novel therapeutic avenues for improving outcomes of cancer treatment. Significance: Two novel p53-responsive microRNAs whose distinct mechanisms of action both stabilize p27 to promote cell quiescence and may serve as therapeutic avenues for improving outcomes of cancer treatment.]]> Thu 28 Oct 2021 12:36:09 AEDT ]]> Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45318 Thu 27 Oct 2022 13:56:46 AEDT ]]> The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45314 Thu 27 Oct 2022 13:56:29 AEDT ]]> LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37758 regenerating islet-derived (REG) gene family are important regulators of many cellular processes. Here we functionally characterise a non-protein coding product of the family, the long noncoding RNA (lncRNA) REG1CP that is transcribed from a DNA fragment at the family locus previously thought to be a pseudogene. REG1CP forms an RNA–DNA triplex with a homopurine stretch at the distal promoter of the REG3A gene, through which the DNA helicase FANCJ is tethered to the core promoter of REG3A where it unwinds double stranded DNA and facilitates a permissive state for glucocorticoid receptor α (GRα)-mediated REG3A transcription. As such, REG1CP promotes cancer cell proliferation and tumorigenicity and its upregulation is associated with poor outcome of patients. REG1CP is also transcriptionally inducible by GRα, indicative of feedforward regulation. These results reveal the function and regulation of REG1CP and suggest that REG1CP may constitute a target for cancer treatment.]]> Thu 27 Jan 2022 15:55:02 AEDT ]]> The double life of RIPK1 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50344 Thu 20 Jul 2023 14:26:55 AEST ]]> BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32504 Thu 14 Apr 2022 10:59:36 AEST ]]> Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21386 Sat 24 Mar 2018 08:05:03 AEDT ]]> Involvement of vacuolar H⁺₋ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26890 Sat 24 Mar 2018 07:41:39 AEDT ]]> Guidelines for the use and interpretation of assays for monitoring autophagy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30350 Sat 24 Mar 2018 07:40:25 AEDT ]]> RIP1 kinase is an oncogenic driver in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26954 Sat 24 Mar 2018 07:27:01 AEDT ]]> The melanoma-associated antigen MAGE-D2 suppresses TRAIL receptor 2 and protects against TRAIL-induced apoptosis in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23422 Sat 24 Mar 2018 07:13:54 AEDT ]]> Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44908 Mon 24 Oct 2022 16:17:34 AEDT ]]> Inhibition of HSP90 by AUY922 preferentially kills mutant KRAS colon cancer cells by activating Bim through ER stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28221 Fri 16 Oct 2020 16:09:46 AEDT ]]> The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49114 Fri 05 May 2023 11:38:54 AEST ]]> RIP1 protects melanoma cells from apoptosis induced by BRAF/MEK inhibitors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36768 Fri 03 Jul 2020 14:41:43 AEST ]]> Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35545 Fri 03 Dec 2021 10:33:29 AEDT ]]>